Screening and Probiotic Properties of Lactic Acid Bacteria with Potential Immunostimulatory Activity Isolated from Kimchi

The modulation of the immune system is a major mechanism through which probiotics exert beneficial effects on health. Probiotics, including lactic acid bacteria (LAB), have been reported to enhance innate immunity. purpose this study was screen for LAB strains with excellent immunostimulatory activity isolated from kimchi. We selected five promising (Limosilactobacillus fermentum MG5489, Lactococcus lactis MG5542, Lacticaseibacillus paracasei MG5559, Latilactobacillus sakei MG5468, and curvatus MG5609) that exhibited immune-stimulating by inducing production nitric oxide (NO) pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β in RAW264.7 cells. significantly increased phagocytic cells nuclear factor-κB (NF-κB) activation. Furthermore, safety determined using hemolysis antibiotic susceptibility tests. stabilities adhesion abilities these gastrointestinal tract (GIT) were also determined. Taken together, findings suggest potential be novel